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Study of the antidrepanocytary properties of an extract of Ficus umbellata leaves

Diouf Ibrahima, Mbaye Sene, Diop Doudou, Absatou Diaw, Toure Maimouna, Diaw Mor, Abdou Sow Khadre, BA Kane Modou Oumy, Sarr Mamadou, Ba Abdoulaye, Diallo Aminata, Samb Abdoulaye.


Background: Sickle cell disease is the most common symptomatic hemoglobinopathies in the world, especially in Black Africa. Herbal medicine becomes an alternative for the treatment of this condition, especially as the African pharmacopeia in general and Senegal, in particular, is widely rich plants with anti-sickle interesting properties.

Aim and Objective: Our study aimed to evaluate the antifalcémiante activity of the extract of leaves of Ficus umbellata.

Materials and Methods: Two solutions hydroethanolic extract of leaves of F. umbellata dosed at 2.5 mg/L and 5 mg/L were prepared. Then, test Emmel was performed with and without the solution of the extract on blood samples from carriers of the sickle cell trait AS, SS, and subjects not having the move. Sickle cell counting by light microscopy at a magnification of 100 was followed.

Results: At baseline in AS subjects, we have a sickle rate of 47%, after adding the extract to 2.5 mg/ml, we have a sickle rate of 18.1%, and after adding the extract 5 mg/ml, the rate rose to 12%. Similarly, in subjects trait carriers SS at baseline, we have a sickle rate of 72.7%, after adding the extract at concentrations, 2.5 and 5 mg/ml rates increased, respectively, 32.5% and 20%.

Conclusion: The results showed that the leaf extract of F. umbellata induced a significant decrease in sickle rates. This activity is dose-dependent for
preventing sickling is sharper at high concentrations.

Key words: Prevention; Sickle Cell Disease; Sickle Cell Anemia; Ficus umbellata

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