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Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats

Vijai Sundar E, Sandeep V M, Beyaril Chitra C, Sarath Babu K, Leo David P.


Background: Arthritis is a leading cause of physical disability and impaired quality of life. At present, symptomatic treatment is available for arthritis. According to literature, apigenin possess anti-inflammatory activity.

Aims and Objectives: The present study aimed to screen the anti-inflammatory activity of Apigenin in freund’s induced arthritis in Wistar albino rats.

Materials and Methods: A total 30 rats were selected and divided into five groups each of six animals. Group – I (Normal saline), Group – II (Freund’s adjuvant (0.1 ml of 0.5%), Group – III (Dexamethasone 0.1 mg/kg), Group – IV (Apigenin 50 mg/kg), and Group – V (Apigenin 100 mg/kg) doses were administered to their respective groups for 28 days. X-ray was taken on 28th day and animals were sacrificed and affected paw used for histopathological examination.

Results: Group – II rats showed inflammation, thickness, fibro, and fatty changes in joint compared to Group – I X-ray and histopathological examination. Groups – III and V rats showed reduction inflammation, thickness, and fatty changes compared to Group – II. Group – IV showed lesser effect compared Group – V.

Conclusion: Apigenin administration significantly prevent the Freund’s induced radiological and histopathological changes in rats.

Key words: Apigenin; Freund’s; Dexamethasone; Rat Paw; Histopathology; X-ray

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