Asteraceae. We carried out the review based on the 06- PRISMA guideline (14) and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-Analysis Facility (SyRF) database. Various English databases, such as Scopus, PubMed, Web of Science, EMBASE, and Google Scholar were used to find publications about the vasodilation effects of medicinal herbs with no date limitation. Among 2420 papers, 8 papers including up to 2021, met the inclusion criteria for discussion in this systematic review. The obtained results showed that the most common parts used in the studies were aerial parts (40%) followed by leaves (30%) and fruit (10%). The findings of the present review showed that methanolic extract (20%), essential oil (20%), and aqueous extract (20%) were considered as the desired approaches of herbal extraction. The findings of the present review showed that several investigations have been carried out on antihypertensive and vasodilation activity of extracts and essential oils of Asteraceae family alone or in combination with present synthetic drugs. We found that the plant-based vasodilation drugs are considered as an alternative and complementary source for treating hypertension as had lower important toxicity. However, more studies are required to clear this conclusion, particularly in clinical systems.
vasodilation, vasorelaxant, Asteraceae, antihypertensive, extract, essential oil
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