Frontotemporal dementia (FTD) is the second most common group of neurodegenerative disorder following Alzheimers Disease (AD); and characterized by degeneration of frontal and/or temporal lobes. FTD can be classified as behavioral variant FTD (bvFTD) and primary progressive aphasia (PPA). The aim of this study is to investigate electrophysiological differences in bvFTD and nonfluent/agrammatic PPA (naPPA), one of three forms of PPA. Twelve patients with bvFTD and 15 patients with naPPA were included in the study. EEG was recorded from 19 electrode sites based on international 10-20 system. Each participant's data were averaged across the recording epochs for each electrode, and the mean absolute power values were computed for delta, theta, beta and alpha frequency bands. For all frequency bands, inter-hemispheric and intrahemispheric coherence was calculated. In absolute power; decreased theta power at all regions was found in bvFTD group as compared to naPPA group. Regarding coherence; increased beta coherence at left centoparietal region and increased alpha coherence at inter-hemispheric frontal region was found in bvFTD as compared to naPPA group. Our findings suggests that subtypes of FTD vary in resting-state EEG especially indexed by the decreased theta power reflecting bvFTD.
Key words: frontotemporal dementia, behavioral variant, nonfluent/agrammatic, PPA, EEG, quantitative EEG
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