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Ethanolic extract of Moringa oleifera leaves improve inflammation, angiogenesis, and blood pressure in rat model of preeclampsia

Agnes Batmomolin, Ahsan Ahsan, I. Wayan Arsana Wiyasa, Sanarto Santoso.


Abstract

The aim of the study is to investigate the effect of ethanol extract of Moringa oleifera leaves (EMOL) to improve inflammation, angiogenesis, and blood pressure by evaluate serum level of IL-17, sFlt-1, and blood pressure in rat model of preeclampsia (PE). Rat model of PE were induced with Nω-nitro-L-arginine methyl ester (L-NAME) 50 mg/kg body weight (b.w) on day 12-18 of gestation. On day 5 of gestation three groups are given EMOL dose 50,100, and 200 mg/kg b.w, one group administered aspirin 1.35 mg/200 gr b.w. Blood pressure were measurement on day 0,11 and 19 of gestation. On day 20 of gestation, rats were sacrificed, serum parameters were analyzed. There is significant difference in serum level of IL-17 in all of groups (p˂0.05). EMOL doses 50 and 100 mg/kg b.w prevent increase of serum level of IL-17 better than low dose aspirin (p˂0.05). There was a tendency decrease sFlt-1 serum levels with EMOL doses of 50 and 100 mg/kg b.w, but statistically there is no significant differences (p>0.05). All doses of EMOL have the same effect as low-dose aspirin to prevent blood pressure increase in rat model of PE (p˂0.05).

Key words: EMOL, IL-17, sFlt-1, blood pressure, prevention preeclampsia






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