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The Effectiveness of Combination Serum of Tranexamic Acid, Galactomyces Ferment Filtrate, Niacinamide And Alpha Arbutin in Enhancing Skin Brightness

Grace Lauren Santoso,Anis Irawan Anwar,Farida Tabri,Khairuddin Djawad,Asnawi Madjid,Arifin Seweng.


Introduction: Light skin tone has been desired by many Asian women thus the search of effective depigmenting agent has been conducted by many researchers. Tranexamic acid, an anti-fibrinolytic drug, is now gaining popularity as a new depigmenting agent. However, studies on tranexamic acid have shown mixed result of its comparison to hydroquinone. Galactomyces ferment filtrate, niacinamide and alpha arbutin have been known of their depigmenting effect. Combined materials with different targeting mechanisms are used to enhance the effectiveness of the lighting agent
Objective: To compare the skin lightening effect of combination of tranexamic acid 3%, galactomyces ferment filtrate 2%, niacinamide 4%, and alpha arbutin 2% to hydroquinone 4%.

Methods: In this study, each of 30 participants applied a combination of tranexamic acid 3%, galactomyces ferment filtrate 2%, niacinamide 4%, and alpha arbutin 2% and hydroquinone 4% to the left forearm using a special patron. Subject then evaluated each week for four weeks. Clinical effects were evaluated using a chromameter including L* for skin brightness and a* for skin erythema. All measurements were taken three times, and the mean value was used. To assess the comparison of skin brightness score and pigmentation intensity between the two serum groups, the Independent T-test was used. As for assessing the change in scores based on measurement time in each serum group, Pearson's Correlation was used. The test results are significant if the value of p

Key words: Depigmenting, tranexamic acid, galactomyces ferment filtrate, niacinamide, alpha arbutin

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