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Dobesilate an old drug as a possible new treatment option for COVID-19 infection

Pedro Cuevas, Javier Angulo, Daniel Zingg, Antonio Manquillo, José Luis Calleja, Guillermo Giménez-Gallego.


Abstract

COVID-19 pandemic is responsible for near to two million deaths worldwide. Because of the lack of any specific treatment option, repurposing of existing drugs continues worldwide in order to find immediate therapeutic strategies for deadly SARS-CoV-2 infection. We recently demonstrated the efficacy of Dobesilate, an old medicament with a long history of use with proven efficacy and good safety profiles, in a patient suffering from COVID-19 disease. The postulated therapeutic mechanism of Dobesilate in COVID-19 disease may primarily involve the following effects: reducing infection-related pathways, suppressing inflammation-related pathways (cytokine storm), protecting capillary barrier permeability, alleviating thrombosis and perivascular oedema, and ultimately attenuating interstitial fibrosis.

Key words: SARS-CoV-2, COVID-19, Dobesilate, FGF, VEGF






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