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The relationship between autoimmunity and HbA1c in type 1 diabetes mellitus patients

Dilvin Celik Ates, Aysehan Akinci, Ismail Dundar.


Indicators of increased risk for type 1 diabetes (T1DM) are specific antibodies that are mainly immune markers. Islet cell antibody (ICA), insulin autoantibody (IAA), glutamic acid decarboxylase enzyme antibody (GADA) and HgA1c are also used in the diagnosis and follow-up of patients with type 1 diabetes mellitus. ICA, IAA, GADA, HbA1c were checked at the time of diagnosis and at 6-month intervals in pediatric patients monitored with T1DM. Decreased ICA, GADA and HbA1c levels were evaluated as good blood glucose control and good clinical response. Patients aged ≤5 years had a higher rate of IAA and patients aged >5 years had a higher rate of ICA. Antibody selection according to age during diabetes screening was found to be significant in terms of cost.

Key words: Diabetes mellitus, autoantibody, glycolyzed hemoglobin

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