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Original Article



Effects of high dose vitamin C administration in Covid-19 patients

Fatih Simsek, Hasan Yonca, Irmak Tahmaz, Umut Kara, Ender Sir, Sami Eksert, Mehmet Emin Ince, Serkan Senkal, Ilker Ozdemirkan, Ufuk Turan, Umit Savascı, Deniz Dogan, Canturk Tasci, Ertugrul Yazici, Gulden Yilmaz, Ahmet Cosar.

Abstract
There is currently no pharmacotherapy with for the treatment of COVID-19. We aimed to investigate the effects of early and high-dose vitamin C (VC) therapy in hospitalized patients with COVID-19.
Materials and Methods: We included patients (n=139) who received high-dose VC supplement to the standard treatment protocol into group 1 (n=58), and only those who received a standard treatment protocol into group 2 (n=81). The patients' requirement for supplemental oxygen therapy, requirement for intensive care treatment and survival rates was investigated retrospectively. Furthermore, the changes in white blood cell, C-reactive protein (CRP), procalcitonin, D-Dimer, renal function tests, ferritin, and interleukin 6 values during hospitalization were evaluated.
Results: When the groups were compared in terms of clinical data, there was no significant difference in terms of the patients requiring supplemental oxygen therapy (p=0.808), requiring intensive care (p=0.662), and survival rates (p=0.185). However, a significant difference was observed between the groups in terms of changes in renal function tests, and CRP values (p

Key words: Ascorbic acid; coronavirus; kidney function tests; severe acute respiratory syndrome; pneumonia



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