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Egypt. J. Phycol.. 2020; 21(1): 1-18

Bioactive constituents of three algal species extracts and their anticancer activity against human cancer cell lines

Olfat M.A Salem, Reham K. El Assi, Mohamed A. Saleh.

This study was designed to Identify the bioactive constituents of red alga Gracilaria dendroides and two microalgae Chlorella vulgaris (green alga) and Microcystis sp. (blue green) by GC /Mass and HPLC analysis and assay the cytotoxic activity of the methanolic extract from the three species against three types of human cancer cell lines (liver HEPG-2, colon, and breast MCV-7) The research was performed as an in vitro study. The effect of extract on proliferation of cell lines were measured by MTT colorimetric method. The results showed that the compound identified by GC-MS were 19,11, 12 in G. dendroides, Chlorella and Microcystis respectively. HPLC analysis identified 4 compounds in Gracilaria and 6 compounds in Chlorella and Microcystis. Concerning MCF-7 cell line, the most potent crude extract was the G. dendroides (IC50 value of 93.23 g/ml). crude extract of Gracilaria had the strongest activity on HepG-2 cell lines with IC50 value 70.03 g/ml. the cytotoxic activity against epithelial colorectal adenocarcinoma cells (CaCO-2) showed higher activity for Chlorella vulgaris with IC50 = 46.11 g/ml.

Key words: Anticancer, Bioactive compounds, Gracillaria, Chlorella, Microcystis

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