Abstract

Aim and Background
Ramelteon is a melatonin receptor agonist drug that is also used in urinary tract infections. Melatonin is known to have an effect on smooth muscle contraction. In this study, we aimed to question whether ramelteon exerts a melatonin-like effect on bladder contractions.
Material Methods
Wistar-albino (n = 7) intact female rats were used in the study. After decapitation, 1.5x5 mm bladder strips were examined in an isolated organ bath in which there was Krebs-Henseleit solution. After the regulation period, ramelteon was applied non-cumulatively in two separate doses of 0.2μM, 1μM. The area under the curve (AUC) and peak to peak (p-p) values before and after the application were normalized as% change. Statistical analysis of the data was evaluated using the paired T test in the SPSS 22.0 program.
Results
Exposure of bladder strips to ramelteon significantly increased contractions. Ramelteon caused a statistically significant increase in p-p, AUC values of spontaneous bladder contractions at a dose of 0.2 and 1μM (P

Key words: Ramelteon, Urinary Bladder, Isometric Contraction, Rat