Background: Dewandaru plant (Eugenia uniflora L.) is a plant that contains flavonoids with anti-inflammatory, anti-allergy and antioxidant effects that have various clinically proven benefits.
Aims: To determine the effectiveness of Dewandaru (Eugenia uniflora L.) leaf crude extract on total IgE levels in Wistar rats with ovalbumin-induced allergic rhinitis.
Methods: This is a true experimental study with a randomized post-test-only control group design. This study used 28 male Wistar rats randomly divided into 4 groups (n=7 in each group), i.e. negative control group (without therapy), 100 mg/kg BW in extract group, 200 mg/kg BW in extract group, and positive control group (mometasone furoate). Rats were sensitized with ovalbumin intraperitoneally for 14 days, followed by intranasal ovalbumin exposure on the 15th day for 14 days with intervention. Nasal symptom scores and IgE serum levels were assessed in all groups.
Results: There were significant differences in nasal symptoms scores between groups. Nasal symptom scores were significantly lower in the positive control group and treatment group than in the negative control group (p
Key words: Allergic rhinitis, rat, flavonoid
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