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Review Article

SRP. 2020; 11(1): 315-325


Nephroprotective Potential Effect of Quercttin in Renal Ischemia Reperfusion Injury in Rat Model (Role of Akt/m TOR Pathway)

Rusul F. Hasan, Murooj L. Altimimi, Hayder M. Alaridy, Najah R. Hadi.




Abstract

Ischemia reperfusion is determined by a limitation of blood supply to the organs and subsequent blood restoration and reoxygenation. Renal ischemia reperfusion injury (IRI) is a potential element in the pathogenesis of acute kidney injury arising from oxidative stress, inflammation and apoptosis of renal tubular cells. The mammalian target of rapamycin (mTOR) pathway activates after IRI and contributes to renal repair and regeneration. Quercetin is a flavonoid compound that presents in many fruits and vegetables. Quercetin is widely used for its anti-inflammatory and anti-oxidant effects. The present study aimed to investigate the potential protective effect of quercetin on renal IRI in rat model by regulation of Akt/mTOR pathway. At the end of experiment, the serum levels of urea and creatinine and renal tissue levels regarding p-mTOR, p-Akt, IL-1β, caspase-3, and F2-isoprostane were recognized to be significantly (p value

Key words: IRI, manti-inflammatory effect, AKt /m TOR IRI






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