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Review Article

SRP. 2020; 11(1): 174-178

Clinical Efficacy of Tongxinluo Capsules in Vietnamese Patients with Stable Ischemic Heart Disease: An Open-label Clinical Trial

Sy Van Hoang, Kha Minh Nguyen, Nguyen Phuc Huynh, Binh Quoc Nguyen, Khoi Van Nguyen.

Background: The aim of treatment of stable ischemic heart disease is not only to improve prognosis but also to decrease symptoms and increase the patientís quality of life. Pharmaceutical therapy remains the cornerstone of stable angina treatment, and Tongxinluo is a traditional oriental medicine used in the treatment of ischemic heart disease.
Objective: To evaluate the effectiveness of Tongxinluo for improving angina symptoms and exertion ability in Vietnamese patients.
Methods: This open-label clinical trial was conducted as one branch in 300 Vietnamese patients at Cho Ray Hospital. The diagnosis of stable angina followed the 2013 European Society of Cardiology Guidelines. The patients were supplemented with Tongxinluo at a dose of 6 tablets bid. Patients were reassessed for angina symptoms and any subclinical side effects of the drug at 2 weeks and 6 weeks after initiation of the drug treatment.
Results: Exercise time on rolling mats, metabolic equivalents (METs), and other subclinical indices were decreased significantly after 6 weeks of Tongxinluo administration. Side effects of halitosis, a burning sensation, diarrhea, and headaches were mild and tolerable.
Conclusion: Tongxinluo provides a significant reduction in the frequency, duration, and severity of angina. Tongxinluo was well tolerated by this Vietnamese study population.

Key words: angina, cardiology, oriental medicine, Tongxinluo, Vietnam.

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