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Original Article

ECB. 2013; 2(11): 916-919


L-PROLINE-CATALYZED SYNTHESIS OF FUSED DIHYDROPYRIDINES THROUGH HANTZSCH REACTION

Farahnaz K. Behbahani, Mahsa Mohammadloo.




Abstract

An efficient Hantzsch four-component condensation reaction for the synthesis of polyhydroquinolines was found to proceed in the presence
of L-proline in ethanol at room temperature. The method is really simple and environmentally benign. The keys features of this protocol are
the use of a bio, organic and reusable catalyst, high yields of products, using nontoxic solvent and short reaction times from the principles
of green chemistry point of view.

Key words: Synthesis; Polyhydroquin‾ L-pr‾ Catalyst; Four components






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