Objective: To evaluate the effect of injection of remifentanil with propofol in decreasing the
undesirable anesthetic airway responses such as coughing and gagging.
Methods: We performed a randomized double-blind study from October 2003 to May 2004, in
Emam Hospital in Tabriz, Iran, to compare the condition during insertion of LMA in 90 patients
with ASA classes I and II, in 3 groups. Group R1 received 0.25 μg/kg remifentaniel and 2.5
mg/kg propofol, Group R2 0.5 μg/kg remifentanil and 2.5 mg/kg propofol, and Group P normal
saline and 2.5 mg/kg propofol. Hemodynamic changes, apneic time, condition of insertion and
airway patency were compared in these groups.
Results: Remifentanil significantly improved the condition of insertion in-group R1: 80.33% and
group R2: 90.6% in comparison with group P 40%. Hemodynamic changes in-group R1 was less
than R2. Patients in-group R1 were apneic for a mean time of 1.75 ± 0.9 min as compared with
2.35± 1.3 min in-group R2.
Conclusion: Administration of 0.25-μg/kg remifentanil with 2.5 mg/kg propofol caused less
hemodynamic changes and provided excellent condition for insertion of the LMA.(Rawal Med J
2007;32:8-10)
Key words: Airway, remifentanil, propofol, intubation.
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