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Original Article

J App Pharm Sci. 2019; 9(4): 117-125


Combined effects of celecoxib and cepharanthine on human colorectal cancer cells in vitro

Parawee Lerdwanangkun, Piyanuch Wonganan, Robin James Storer, Wacharee Limpanasithikul.




Abstract
Cited by 1 Articles

Colorectal cancer is one of the most common cancers worldwide. We investigated effects of celecoxib (CLX)–cepharanthine (CEP) in combination on HT-29 human colorectal cancer cells. CLX at 5, 10, 20, or 40 µM in combination with CEP at 1.25, 2.5, or 5 µM displayed synergistic cytotoxic effects with a combination index

Key words: celecoxib, cepharanthine, colorectal cancer, apoptosis, cell cycle






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