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Original Article

ECB. 2013; 2(8): 573-575


SYNTHESIS OF UNSYMMETRICAL THIOUREA DERIVATIVES

Asieh Yahyazadeh, Zahra Ghasemi.




Abstract

A series of thiourea derivatives have been synthesized. Thiourea derivatives show a broad spectrum of biological activities such
as antibacterial, antiviral, anticancer, anticonvulsion, analgesic an HDL-elevating. Ethyl isothiocyanate and aromatic amines were
mixed and stirred at room temperature in acetone for 15 h to give the corresponding thioureas in high yields. Their structures
were confirmed by IR and 1H-NMR. By addition e-donor groups to aromatic amines, thioureas were synthesized in high yields

Key words: substituted anilines, ethyl isothiocyanate, unsymmetrical thiourea derivatives






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