Objective: To evaluate the current trend of antimicrobial susceptibility pattern of Salmonella typhi and paratyphi.
Methodology: This observational laboratory based study was conducted at Department of Microbiology, Khawaja Muhammad Safdar Medical College, Sialkot from January 1, to June 30, 2019. Blood culture samples were collected aseptically, sub cultured and identified as Samonella typhi or paratyphi A, as recommended by clinical laboratory standard institute.
Results: A total of 2773 samples were collected, among these 1945(70%) were from neonates and were excluded from the study. Among rest 828(30%) blood culture samples, 55(6.64%) yielded growth of Salmonella typhi and paratyphi. Out of total Salmonella species, 44(80%) were Salmonella typhi and 11(20%) were Salmonella Paratyphi A. Multidrug resistant salmonella were 47% and extensively drug resistant salmonella were 16%. Meropenem and azithromycin showed 100% sensitivity while ceftriaxone in 84% cases.
Conclusion: Trends of antibiotic susceptibility are changing as flouroquinolones are less effective than first line drugs. Extensively drug resistant cases of typhoid are also detected, which needs regular monitoring of sensitivity pattern.
Key words: Antibiotics,resistance, MDR salmonella, XDR salmonella.