Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

Novel glitazone attenuates rotenone-induced toxicity in mouse model of Parkinsonís disease

Ankith B. Shetty, Kamsagara Linganna Krishna, Bommenahally Ravanappa Prashantha Kumar, Hittanahalli Shivakumar Nandini.

Parkinsonís disease (PD) is the second most common neurodegenerative disorder, and there are no drugs that will directly tackle the inflammatory component of PD. In the present study, we assessed the novel glitazone for reversal of rotenone-induced toxicity in experimental mouse model. The 14 virtual glitazone compounds were subjected to molecular docking study for target protein 3CS8; among these, compound C25 and C34 have shown better binding activity. Pharmacokinetics studies were conducted for the above compounds in rat model to chose best one for further toxicity and efficacy studies. The compound C25 showed better kinetic profile when compared to C34 and better t1/2 when compared to the standard pioglitazone. Compound C25 then tested for acute toxicity by OECD guideline 423 and evaluated for its neuroprotective activity in mouse model. The activity of the compound was assessed by the behavioral parameters on weekly intervals during the study period and estimated the antioxidant level in the brain homogenate. The compound has shown good activity dose-dependently; however, further research is required to confirm its activity and to support our hypothesis.

Key words: 3CS8, Docking, PPARő≥, Glitazones, Parkinsonism, Kinetics

Similar Articles

Visible light photodegradation of 2,4-dichlorophenol using nanostructured NaBiS: Kinetics, cytotoxicity, antimicrobial and electrochemical studies of the photocatalyst.
Kumar VGD, Balaji KR, Viswanatha R, Ambika G, Roopa R, Basavaraja BM, Chennabasappa M, Kumar CRR, Chen Z, Bui XT, Santosh MS
Chemosphere. 2022; 287(Pt 2): 132174

In vitro and in silico anti-osteoporosis activities and underlying mechanisms of a fructan, ABW90-1, from Achyranthes bidentate.
Li T, Hou X, Huang Y, Wang C, Chen H, Yan C
Carbohydrate polymers. 2022; 276(): 118730

Ultrahigh Throughput Protein-Ligand Docking with Deep Learning.
Clyde A
Methods in molecular biology (Clifton, N.J.). 2022; 2390(): 301-319

Predicting Residence Time of GPCR Ligands with Machine Learning.
Potterton A, Heifetz A, Townsend-Nicholson A
Methods in molecular biology (Clifton, N.J.). 2022; 2390(): 191-205

Structure-property relationship in thioxotriaza-spiro derivative: Crystal structure and molecular docking analysis against SARS-CoV-2 main protease.
Mahesha , Udaya Kumar AH, Vindya KG, Pampa KJ, Rangappa KS, Lokanath NK
Journal of molecular structure. 2022; 1250(): 131746

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMedģ Information Services.

ScopeMed Web Sites