Home|Journals|Articles by Year|Audio Abstracts
 

Original Research

RMJ. 2022; 47(2): 354-357


Serum IgE as a prognostic marker of fungus in chronic rhino sinusitis with nasal polyposis

Amna Khalil, Sadaf Zia, Iqbal A Muhammad Khyani.




Abstract

Objective: To assess the relationship of total serum IgE level in anticipating the manifestation of fungus in chronic rhinosinusitis with nasal polyposis (CRSwNP).
Methodology: This observational study was carried out at Dow University Hospital, Dow International Medical College, DUHS, Karachi from June 2015 to June 2017. Patients with CRSwNP diagnosed on anterior rhinoscopy and rigid nasal endoscopy were treated medically for 1 month by clarithromycin 500mg daily for 30 days, topical nasal steroids (mometasone furoate 200 μg daily, or fluticasone furoate 110 μg daily), and oral steroid therapy (methylprednisolone 0.5 mg/kg/day with tapering off doses).
Results: Twenty-six patients (29.9%) had a positive culture for fungus; however, the double density sign was positive in 25 (28.7%) patients and 39 (44.8%) patients were suspected of having fungus during surgical exploration of sinuses.
Conclusion: A strong association between raised degrees of serum IgE with polyps, intensifying polyp seriousness, and AFS, which in general can be used as a screening for the presence and reaction to treatment of fungal infection in paranasal sinuses prompting early acknowledgment of AFS.

Key words: Nasal polyps, allergic fungal sinusitis, serum IgE level.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.