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Original Article

ECB. 2013; 2(7): 465-467


A CONVENIENT WAY FOR THE PREPARATION OF NOVEL THIOUREA DERIVATIVES CONTAINING BIOLOGICALLY ACTIVE QUINAZOLINE MOIETY

Sohail Saeed, Rizwan Hussain.




Abstract

A series of new thiourea derivatives containing quinazoline-4(3H)-one framework (3a-d) was successfully synthesized and characterized
by IR, 1H NMR, 13C NMR spectroscopy, ESI mass spectrometry and elemental analysis. Variation in the functional group at the phenyl
ring led to set of compounds bearing quinazoline-4(3H)-one accommodated substituted phenyl thioureas.

Key words: Heterocyclic thiourea derivatives, quinazolin-4(3H)-one moiety, phenyl isothiocyanates






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