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Case Report

Renal amyloidosis causing nephrotic syndrome: An unusual presentation of light chain myeloma

Madhukar Rai, Jaya Chakravarty, Manaswi Chaubey, Nayana Bhuyan, Arijit Pal, Rishab Jaiswal.


Light chain myeloma represents 20% of multiple myeloma cases. Renal amyloidosis is one of the manifestations of light chain myeloma. Here, we present a case of nephrotic syndrome which was later diagnosed by kidney biopsy to be renal amyloidosis. Cumulative analysis of routine investigations, bone marrow analysis, immunofixation, and skeletal radiography confirmed it to be a case of light chain myeloma. The patient was later started on VRD regimen (lenalidomide, bortezomib, and dexamethasone) and responded well to the treatment.

Key words: Light Chain Myeloma; Renal Amyloidosis; Nephrotic Syndrome

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