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IJMDC. 2020; 4(2): 509-512

Uses of diuretics in heart failure: a brief review

Abdulaziz Dhafer Algarni, Wejdan Talal Almutairi, Asawir Mohammed AlQurashi, Esraa Abdulrahman Alshehrani, Wijdan Turki Almrzouqi, Hussain Ali Alhazmi.


Heart failure (HF) is a disorder that affects at least a minimum of 26 million humans over the world, and its prevalence keeps growing. HF health expenses are large and will elevate dramatically with an older populace. Despite the progress in treatment strategies and prevention, death rate and morbidity remain rising. This study included all the studies which focused and reported the uses of diuretics in HF. A filtration procedure was used to remove duplicates, irrelevant publications. The online databases PubMed and Google Scholar and Research gate were used to perform a literature search for publications published between 1995 and 2019, without any date or language restrictions. We used a combination of relevant search terms "treatment of heart failure by using diuretics, the role of diuretics in the treatment of heart failure, loop diuretic therapy in heart failure, etc." to discover articles regarding the matter. We independently identified publications and systematically screened titles, abstracts, and full texts of the collected publications. However, the studies available on extensive use of diuretics and its capability to control HF-related mortality and morbidity are very limited. Diuretics are a valuable and diverse class of agents for the controlling of hypervolemic cases. This review summarizes the essential characteristics of diuretics, involving their mode of action and significances.

Key words: Heart failure, diuretic therapy, loop diuretics, thiazide diuretics, potassium-sparing diuretics, diuretic resistance

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