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Original Article

NMJ. 2019; 8(2): 64-71


COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Sai Sudha L,Ashalatha P,Krishna Chaitanya K.

Abstract
OBJECTIVE:
To compare the anaesthetic effects of a 3-drug mixture – IV Magnesium sulphate, IV Dexamethasone, IV Loxicard ; and IV Dexmedetomidine in suppressing the hemodynamic stress response to laryngoscopy and endotracheal intubation.
MATERIALS AND METHODS:
60 patients were divided into two equal groups of 30 in each group were enrolled in this study. GROUP M – received 1g MgSO4, 8mg dexamethasone, 1.5mg/kg Loxicard in 100ml NS given over 10mins (n=30) GROUP D – received 1mcg/kg dexmedetomidine in 100ml NS given over 10 mins (n=30) ; prior to induction of anaesthesia. Both the groups were observed for changes in hemodynamic parameters like HR, SBP, DBP at 0, 1, 3, 5, 10 minutes after laryngoscopy and intubation.
RESULTS:
Comparison of both the groups reveals that HR response post intubation was better attenuated with dexmedetomidine with statistically significant p values at all time intervals. Attenuation of blood pressure with dexmedetomidine at 0,1 min post intubation had statistically significant p values (SBP at 0min(p-0.003) ,1 min(p-0.01) and DBP at 0min(p-0.04), 1min(p-0.04) , whereas there was no statistically significant difference in blood pressure at 3,5,10 minutes post intubation between both the groups.
CONCLUSION:
The increase in heart rate was better attenuated with dexmedetomidine and blood pressure was as effectively attenuated with the 3-drug mixture when compared to dexmedetomidine. Hence, this mixture can be used as an effective and safe alternative to dexmedetomidine.

Key words: Stress response, Dexmedetomidine, 3-drug mixture, heart rate, blood pressure, laryngoscopy, intubation.



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