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Review Article

IJMDC. 2020; 4(1): 267-270

The relationship between H. pylori infection and gastric cancer: a review

Radad Saad Alqahtani, Hasan Hayaza Albarqi, Faisal Ali Alqarqah, Osama Jamaan M. Alzahrani, Maram Mudhhi N. Alabdali, Ahmed Saeed Y. Alasiri.


Gastric cancer is considered as one of the most frequent types of cancer globally. One of the proposed mechanisms of gastric cancer is Helicobacter pylori infections. Hence, understanding of pathogenesis, risk factors, and treatment of H. pylori is crucial to reduce the incidence of gastric carcinoma. This review paper aimed at evaluating the literature on the correlation between infection with H. pylori and gastric cancer. In this review, medical databases were examined thoroughly to explore the eligible articles for inclusion. Twenty-seven articles appeared in the search result. The produced reports were evaluated against the pre-decided inclusion criteria. After reviewing the literature, six articles were eligible to be included in this review. The included articles were published between 2012 and 2019. This review concludes that there is a strong correlation between infection with H. pylori and the occurrence of gastric cancer. Therefore, early and effective eradication of H. pylori can reduce the incidence of gastric cancer drastically.

Key words: H. pylori, gastric cancer, relationship

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