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Original Research

RMJ. 2007; 32(2): 146-149


Adenosine Deaminase Organic Effectors in Normal and Abnormal Cerebrospinal Fluid

Amina Hamed Ahmad Al& 8211;Obaidi, Abdul& 8211;Ghani Mohamed Ali Al& 8211;Samarai Abdul Monem Hamad Majed Al& 8211;Samarai.




Abstract

Objective: To study the effect of the organic substances on adenosine deaminase
(ADA) activity in normal and abnormal cerebrospinal fluid (CSF).
Methods: Various concentrations of 2-mercaptopurine, Ame‚ÄĚtycine, Adenosine
analogues (Guanine, Thymine ) and ATP were tested to see their effect on ADA
activity in normal and abnormal CSF.
Results: ADA activity in normal and abnormal CSF was remarkably decreased with
the increasing of concentrations of substances tested.
Conclusion: These effects may have important therapeutic implications. (Rawal Med
J 2007;32:146-149).

Key words: Adenosine deaminase, CSF, Organic inhibitors, ATP, AMP.






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