|RMJ. 2007; 32(2): 146-149
Adenosine Deaminase Organic Effectors in Normal and Abnormal
Amina Hamed Ahmad Al& 8211;Obaidi, Abdul& 8211;Ghani Mohamed Ali Al& 8211;Samarai
Abdul Monem Hamad Majed Al& 8211;Samarai.
Objective: To study the effect of the organic substances on adenosine deaminase
(ADA) activity in normal and abnormal cerebrospinal fluid (CSF).
Methods: Various concentrations of 2-mercaptopurine, Ame”tycine, Adenosine
analogues (Guanine, Thymine ) and ATP were tested to see their effect on ADA
activity in normal and abnormal CSF.
Results: ADA activity in normal and abnormal CSF was remarkably decreased with
the increasing of concentrations of substances tested.
Conclusion: These effects may have important therapeutic implications. (Rawal Med
Key words: Adenosine deaminase, CSF, Organic inhibitors, ATP, AMP.