Abstract

A new series of 6-(aryl)-3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-4-phenylpyrimidine-2(1H)-thione
derivative (5A-5J) have been synthesized from 6-(substituted aldehyde)-4-phenylpyrimidine-2(1H)-thione derivative (4A-4J) by the
Claisen-Schmidt cyclization and Satos fusion. The structures of the synthesized compounds were elucidated by IR, 1H NMR, elemental
analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vitro antioxidant activity using the
DPPH(2,2 diphenyl 1-picrylhydrazyl) assay. The activity summarized by antioxidant activity unit (AAU) and antioxidant activity index
(AAI). The antioxidant strength of compounds was compared against ascorbic acid. Among them, compounds 5A, 5D, 5E, 5F exhibited
significant antioxidant activity.

Key words: : Thiones; synthesis; antioxidant activity index;