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Case Report

A patient with hereditary angioedema and systemic lupus erythematosus: Coincidence or coexistence?

Gokhan Aytekin, Fatih Colkesen, Eray Yildiz, Sevket Arslan.


Angioedema is classified into two major groups: mast cell-mediated (histaminergic) and bradykinin-mediated angioedema. Hereditary angioedema and acquired angioedema are well-defined groups of bradykinin-mediated angioedema. Both hereditary angioedema and acquired angioedema demonstrate a similar clinical presentation and can be challenging to differentiate. The prevalence of autoimmune diseases is higher in patients with HAE and lupus is an autoimmune disease associated with HAE. In this case, we aimed to present a male patient who was monitored with the diagnosis of HAE and developed systemic lupus erythematosus (SLE) in the follow-up and to discuss whether the patient had hereditary angioedema and concomitant lupus, or acquired angioedema secondary to SLE.

Key words: Hereditary angioedema, lupus, hemolytic anemia, acquired angioedema

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