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Original Research

RMJ. 2008; 33(1): 52-55

Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.

Isam Hamo Mahmood.

Objective: To investigate the effects of two well known antihypertensive drugs
captopril and amlodipine on serum uric acid level in type 2 diabetic hypertensive
Methods: One hundred hypertensive type 2 diabetic patients were divided into two
groups, with 50 patients in each group. Group 1 was given captopril and group 2
amlodipine. A control group was included. Blood pressure and uric acid level were
measured before and after drug administration.
Results: A significantly higher levels of uric acid were found in the diabetic
hypertensive patients as compared with control group. A significant drop of uric acid
was noted after treatment with both captopril and amlodipine. Reduction of uric acid
after therapy with captopril (49.930.34) and amlodipine (31.430.1) showed
significant difference (P

Key words: Hyperuricemia, diabetes, hypertension, captopril, amlodipine.

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