This review provides background knowledge, pathophysiology, and analyzation of patterns in the medications suggested among various medical care specialties for the therapy of cold sores. PubMed, Embase, and web of science databases were searched for all published studies that discussed pathogenesis and complications that herpes cause to the human body, through last 20 years up to 2019. It was reported that the Herpes virus
belongs to infectious diseases; therefore, it is very important to increase the awareness of patients about its infectious nature, such as hepetic lesions or asymptomatic viral dropping. It is good to learn, how to avoid infection of other sites either individually through autoinoculation or by transmission to other persons. Hence, patients should learn and follow some precautions, such as washing their hands regularly, definitely after any topical remedies, and prevent sharing of own utensils. Although the application of topical therapy by using of acyclovir or penciclovir as a lotion was very useful due to its high specificity to the lesion website, but using of oral medicine was more effective for more suppression and sometimes used as a prophylactic for prevention of cold sore.
Key words: Pathogenesis, cold sore, Herpes virus, Herpes simplex labialis
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