Purpose: Endotracheal intubation with succinylcholine causes an undesirable rise in IOP. Clonidine, a selective alpha 2 agonist reduces IOP and provides better hemodynamic stability. Ivabradine, a sinus node inhibitor, shows attenuating effects for hemodynamics. The aim of this study is to compare the effectiveness of both these drugs as premeditates on IOP changes post-intubation with succinylcholine.
Methods: A hospital-based analytical comparative study was done on 105 patients in the age group 18-50 years scheduled for elective surgeries under general anaesthesia. The patients were randomly allocated into three groups of 35 each by computer-generated randomized tables. Group I was given oral ivabradine, Group II was given oral clonidine and Group III received a placebo 1 hour before intubation. IOP was measured just before premedication (T0), just before intubation (T1), just after induction of anaesthesia (T2), 2 minutes after intubation (T3), 5minutes after intubation (T4), 8minutes after intubation (T5), 10 minutes after intubation (T6). P
Key words: Intraocular Pressure (IOP), Clonidine, Ivabradine
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