Pyrrolopyrimidines are well known scaffold which play a critical role as anticancer agents so it thought of interest to synthesize series of novel substituted pyrrolo[2,3-d]pyrimidines having diverse groups at position C4 and N7 of the pyrrolo[2,3-d]pyrimidine core and performed in vitro screening against MDA-MB-468 (breast cancer cell line) cell line. The details of the synthetic methods and characterization data of the synthesized compounds have been presented in this study. Compounds 8a, 8h, 8j, 9h, 9i, 9j, 9m, 9n, 9o showed excellent anticancer activity compared to standard doxorubicin IC50 value 6.17 µM/ml on MDA-MB-468 (breast cancer cell line) which was non-toxic to normal vero cell line.
Key words: Doxorubicin, Pyrrolo[2,3-d]pyrimidine, Anticancer, Breast cancer
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