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Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus

Pande Ketut Kurniari, I Putu Bayu Triguna, Gede Kambayana, Tjokorda Raka Putra.




Abstract

Introduction: Osteoporosis often occurred in SLE patients, one of the mechanisms involved increased homocysteine levels and oxidative stress. Homocysteine levels greatly affect osteoclast and osteoblast activity. Two crucial proteins are produced by osteoblasts; namely the RANKL activator and OPG receptor.
Purpose: This study aims to prove that there is a relationship between serum homocysteine and osteoprotegerin (OPG) levels and bone mineral density in women with systemic lupus erythematosus.
Method: A cross-sectional analytic study with a sample size of 66 females with SLE age 18-50 years. The research variables were age, duration of illness, cumulative dose of corticosteroids, GFR, through interviews and review of medical records. Examination of RANKL and OPG serum by ELISA. BMD examination by Dual Energy X-ray Absorptiometry (DEXA).
Result : A total of 66 female subjects with a mean age of 30.67 ± 8.27 years were included in this study. In bivariate analysis, homocysteine levels had a significant correlation with BMD (r = - 0.250, p = 0.021), serum OPG (r = -0.468, p = 0.000), and serum RANKL (r = -0.368, p = 0.001) . In the multiple linear regression test, the formula for the regression equation is y = 0.1x + (- 4).
Conclusion: The results between homocysteine and OPG levels show an inverse correlation, where the higher the homocysteine level, the lower the serum OPG.

Key words: SLE, Homocysteine, BMD, RANKL, OPG






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