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Anadolu Psikiyatri Derg. 2011; 12(2): 100-106

Prostaglandin metabolite levels in patients with schizophrenia

E. Erdal Erşan, Serpil Erşan, Orhan Doğan.

Objective: Schizophrenia is a neuropsychiatric disease which affects individuals, family members and society.
Although many studies have been carried out on the etiopathogenesis of schizophrenia, the condition is not
entirely understood. In this study, it has been aimed to measure prostaglandin (PG) metabolite levels in patients
with schizophrenia. Methods: The present study measured prostaglandin metabolite levels in 50 schizophrenia
patients and 50 healthy volunteers who were matched for age, sex and smoking is similar in terms of, at least two
years of patient. Measurements were also taken of 13,14-dihydro-15-keto-PGF2α (PGFM) and 13,14-dihydro-15-
keto PGE2 (PGEM). The measurements were performed using High Performance Liquid Chromatography (HPLC)
which is a more sensitive device. Statistical analysis of the data was performed using Student’s t Test, Chi Square
Test, Kruskal-Wallis Test and Mann-Whitney Test. Findings: In the patient group, the PGEM level
(0.0807±0.014, t=3.490, p=0.001) and the PGFM level (0.0613±0.0128, t=-7.486, p=0.000) were both significantly
lower than in the control group (PGEM 0.0907±0.0146; PGFM 0.0793±0.0113). Discussion: These results
suggest that a disorder in phospholipid metabolism may be important in the etiopathogenesis of schizophrenia.

Key words: fatty acids, phospholipid metabolism, prostaglandin, schizophrenia

Article Language: Turkish English

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Oxidants and Antioxidants in Medical Science


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