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Risk Factors Associated With CSF Leak Rates In Extended Approaches For Pituitary Adenomas Endoscopic Endonasal Surgery: A Systematic Review and Protocol

Diana Maria Cespedes Arcani, Chang Jun Cao.

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Over the last two decades the preferred treatment of choice of pituitary adenomas has been extended endoscopic endonasal surgery. However, ongoing CSF leakage is the most common issue for some patients, and contributing to reoperation for repairing is reported. At this point is valuable to identify prognostic factors that influence the CSF leaks rates to make multi-faceted decisions; being as challenging as the technical procedures for neurosurgeons and their team. Objective: The aim of this review is to determine whether preoperative factors are associated with postoperative CSF leaks in extended endoscopic endonasal surgery for pituitary adenoma
Data Sources: A systematic review of published articles undergoing extended endoscopic endonasal surgery for pituitary adenomas between 2000 and 2019 was performed. Including criteria published studies reporting on outcomes of EEEA for pituitary adenomas; 2) no limited language restriction; 3) references list on case report and review articles of extended endoscopic endonasal surgery for pituitary adenoma were also searched; 4) containing original data; 5) adult patients (> 18 years). 6) Eligible study designs include analytic study designs (case-control studies, cohort studies, analytical cross sectional studies.

Key words: CSF leakage, pituitary adenomas, extended endoscopic transsphenoidal approach

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