Home|Journals|Articles by Year

Directory for Medical Articles

Open Access

Original Research

Natl J Med Res. 2019; 9(4): 149-153

Study of association of Methylenetetrahydrofolate Reductase C677T polymorphism with Essential Hypertension in eastern India

Rituparna Maji, Kazi Ashique Firdoush, Anindya Dasgupta.

Introduction: Essential Hypertension (EH) is a complex disease, resulting from the interaction of multiple genetic & environmental factors. Mutation of Cytosine to Thymine at position 677 of methylenetetrahydrofolate reductase (MTHFR) gene causes decreased activity of the enzyme and it has been attributed to essential hypertension in many studies. There is limited data from Indian population on this topic. Hence a case-control study was designed to assess the association MTHFR C677T polymorphism with EH in the eastern Indian subpopulation.
Methodology: Polymerase chain reaction using suitable primer, followed by restriction fragment length polymorphism analysis using Hinf 1 enzyme was used to identify MTHFR C677T genotypes in 207 diagnosed hypertensive patients and 210 matched controls.
Results: Not a single mutant TT genotype was found in either case or control group in our study population. Frequency of heterozygote CT was higher in case group (23.1%) than control (18.2%) but the difference was statistically non-significant (OR: 0.741, 95% CI: 0.430-1.275). Also, no significant difference of allele frequency between the two groups was observed for the polymorphisms studied (OR: 0.767, 95% CI: 0.460-1.278).
Conclusion: Our data shows that MTHFR C677T polymorphism is not associated with the risk of EH in this population.

Key words: Single nucleotide polymorphism, Methylenetetrahydrofolate reductase, Restriction fragment length polymorphism, Essential hypertension, rs1801133, C677T

Similar Articles

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Journal Finder
Covid-19 Trends and Statistics
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.