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Hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a case series

Musa Azhar, Syed Abdul Mannan Hamdani, Shafquat Ali Khan, Abdul Wahab, Jhanzeb Iftikhar, Usman Ahmad, Bushra Ahsan.

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Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hematologic disorder occurring more commonly in children, but there are reported cases in adults as well. It is classified as a primary HLH or secondary HLH, which can occur due to autoimmune diseases, infections, and malignancies. Secondary HLH is a challenge for physicians concerning diagnosis and management.
In this case series, we report two patients of HLH diagnosed between August 2018 and August 2019 at Shaukat Khanum Memorial Cancer Hospital & Research Centre Lahore Pakistan, which were triggered by different underlying conditions like autoimmune diseases and malignancies or a combination of both.

Key words: Familial HLH (FHL), Hemophagocytic lymphohistiocytosis (HLH)

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