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AJVS. 2020; 66(2): 1-10

Effects of Melatonin and Allium sativum (garlic) on Dibutyl Phthalate Induced Oxidative Stress on Serum Hormones and Lipid Profile of Rabbit Bucks

Matthew Shinkut, Peter I. Rekwot, Tagang Aluwong, John S. Bugau, Felix U. Samuel, Elias K. Bawa.


Forty two rabbit bucks were used for this study, bucks were randomly divided into 7 groups of 6 each. Group A was administered olive oil for 16 weeks, group B (olive oil + DBP for 16 weeks), group C (melatonin for 8 weeks, then olive oil + DBP for another 8 weeks), group D (garlic for 8 weeks, then olive oil + DBP for another 8 weeks), group E (olive oil + DBP for 8 weeks, then melatonin for another 8 week), group F (olive oil + DBP for 8 weeks, then garlic for another 8 weeks) and group G (olive oil + DBP for 8 weeks, then melatonin and garlic for another 8 weeks). The study lasted for 120 days, during which blood samples were collected on week 8 and 16 for serum hormonal profile determination and on the 120th day of the study, 3mls of blood was collected during sacrifice of each buck into a non EDTA sample bottle for serum lipid profile determination. Results show significant differences (P < 0.0001) in mean FSH, LH and T concentrations between DBP exposed and treatment groups. The results of serum lipid profile showed significant difference (P = 0.0086), in the mean serum total cholesterol concentration (mmol/L) between group B (4.08 ± 0.09) and groups (C, 2.5 ± 0.39; D, 2.35 ± 0.22; E, 3.2 ± 0.50; G, 2.9 ± 0.29), also there was significant difference (P = 0.0066) in the mean serum triglycerides concentration (mmol/L) between group B (1.83 ± 0.21) and all other groups (A, 0.88 ± 0.14; C, 1.15 ± 0.10; D, 1.28 ± 0.17; E, 1.1 ± 0.12; F, 1.35 ± 0.06 and G, 1.2 ± 0.15). Conclusion DBP decreases the concentration of serum hormones and increases total cholesterol and triglycerides concentration but administration of melatonin and garlic has promising protective effects.

Key words: : Melatonin; Allium sativum; Dibutyl phthalate; Serum hormones; Lipid profile

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