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Original Article

ECB. 2016; 5(6): 232-237


CONVENIENT SYNTHESIS OF NEW 7- METHYLTETRAZOLO[1,5-a]QUINOLINE-4-CARBALDEHYDE DERIVATIVES

Ibrahim Ali M. Radini.




Abstract

7-Methyltetrazolo[1,5-a]quinoline-4-carbaldehyde (1) was reacted with thiosemicarbazide to give the appropriate thiosemicarbazone (2).
Compound (2) was reacted with different α-halocarbonyl compounds such as phenacyl bromide, hydrazonoyl chlorides and α-chloroacetic
acid to afford thiazoles (4), aryldiazenylthiazoles (6), and thiazolidin-4-one (8), respectively. A series of 7-methyltetrazolo[1,5-a]quinoline
derivatives, such as 2-imino-2H-chromene (11), arylacrylohydrazides (13), (15) and (17) and (heteroarylethylidene) acrylohydrazides (19),
(21) and (23) has been synthesized. The structures of the newly synthesized compounds have been confirmed by spectral and elemental
analyses.

Key words: Tetrazolo[1,5-a]quinoline-4-carbaldehyde, hydrazonoyl chlorides, thiazole, chromene.






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