Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article



Negative correlation between TNF-α and triglyceride levels in patients with cerebral infarction

Hikmet Sacmaci, Murat Cakir, Seda Sabah Ozcan.


Abstract

Aim: To investigate the interactions between tumor necrosis factor-alpha (TNF-α) and blood lipid levels in patients with acute cerebral infarction.
Materials and Methods: A total of 43 cerebral infarction patients who applied to the neurology and emergency department of our faculty were included in cross-sectional matched case-control study, and the results were compared with 41 controls who had similar age and comorbidities. In addition to fasting serum lipids, serum glucose, C-reactive protein and hemogram were analyzed as well. Classification of infarct was made. An enzyme-linked immunosorbent test was used to determine baseline plasma TNF-α levels at the time of first admission and potential correlations between the groups were analyzed.
Results: Compared to the control group, the cerebral ischemia group had a higher median TNF-α level (23.53; range, 21.74-43.29 ng/L vs. 23.00; range, 20.62-37.34 ng/L); however, the difference was not significant (p > 0.05). Groups were similar regarding blood lipid values (p > 0.05). In the patient group, TNF-α level showed a negative correlation with triglyceride (TG) and TG / HDL cholesterol (HDL-C) (rho= -0.319 p= 0.037 and rho= -0.321 p= 0.036), whereas no significant correlation was determined in the control group (p > 0.05), on the other hand plasma level of TNF-α was positively correlated with the National Health Stroke Scale score (rho = 0.455 p = 0.002).
Conclusions: Our cross-sectional study revealed an interaction between decreased TG and TG / HDL-C and a high concentration of TNF-α in cerebral infarction for the first time. The importance of our finding is that it provides useful preliminary information, which is necessary for further research in this field.

Key words: Cerebral infarction; inflammation response; triglyceride; tumor necrosis factor alpha






Full-text options


Share this Article



Online Article Submission
• ejmanager.com







eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.