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Toxicological evaluation on male rodents against penoxsulam herbicide used on soil ecosystem

Vidushi Chaurasia, Madan Lal Aggarwal, Nitin Kumar Agrawal, Animesh Agarwal, Anil Kumar, Neeraj Malik, Vishnu D. Rajput, Tatiana Minkina, Manoj Chandra Garg.

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There have been very few comparative studies on male rats evaluating the negative consequences predicted to result from repeated exposure in two separate routes of the herbicide Penoxsulam, which is used on crop soil, due to the ecosystem impact. This study was carried out to examine the repeated toxicity potential of Penoxsulam on male Wistar rats using a dermal topical patch application and oral ingestion route. Five male wistar rats per group of young adults, 12 to 14 weeks old, weighing 200 to 300 grams, were subjected to recurrent topical exposure in this comparative study. While 10 healthy male Wistar rats per group, aged 6 to 8 weeks, and weighing 130 to 190 grams, were utilised for repeated oral exposure. In both investigations, No alteration in body weight, organ weight, feed consumption, biochemical parameters were seen in repeated dermal exposure after post dosing in all male rats While, Penoxsulam herbicide disturbed the physiology of male rats and having significant changes in bodyweight, organ weight, feed consumption, biochemical parameters during the course of repeated 90 days oral exposure. Withall together findings the data agreed that Penoxsulam herbicide (used on crop soil) completely not produce dermal toxicity to the skin after repeated topical patch application to the male rats; However it was deleterious to the male wistar rats and appears to be unsafe for repeated oral ingestion on environment.

Key words: Wistar rats, Male, Oral exposure, Dermal exposure, Penoxsulam, Herbicide

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