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Synthesis, antibacterial, and antioxidant studies of 7-amino-3-(4-fluorobenzoyl)indolizine-1-carboxylate derivatives

Vijayakumar Uppar, Sandeep Chandrashekharappa, Atiyaparveen I. Basarikatti, Govindappa Banuprakash, Mahendra K. Mohan, Mallikarjun Chougala, Kiran K. Mudnakudu-Nagaraju, Raghu Ningegowda, Basavaraj Padmashali.


In the present work, the quaternary salts of 4-aminopyridine i.e., 4-amino-1-[2-(4-bromophenyl)-2-oxoethyl]pyridin-1-ium bromides were obtained by stirring 4-aminopyridine with phenacyl bromides in acetone at room temperature separately. These quaternary salts of 4-aminopyridine were then treated with electron deficient acetylenes, in presence of anhydrous K2CO3 in DMF solvent to get indolizine derivatives. The structures of newly synthesized compounds have been confirmed by spectroscopic techniques like LCMS, 1H-NMR and Elemental analysis. All synthesized compounds were screened for antibacterial and antioxidant activity. The compounds 2e, 2g and 2j shows inhibition zone against bacteria and compounds 2a and 2f moderately active against bacteria. The all compounds 2a to 2j shows DPPH free radical scavenging activity, Nitric oxide free radical scavenging activity, Reducing power scavenging activity and Lipid peroxidation inhibition activity.

Key words: Indolizine, 4-aminopyridine, acetylene, anti-bacterial, antioxidant

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