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Testicular Toxicity Induced by Glyphosate (GLP) and Ameliorative Effect of Vitamin C in Wistar Rats

Moramshetty Lakshmi Namratha, Mekala Lakshman, Mylaram Jeevanalatha, Anil Kumar.




Abstract

The aim of the present experiment was to study the testicular toxicity induced by glyphosate and the protective role of Vitamin C in male albino Wistar rats. Forty eight (48) rats were randomized into four groups consisting of twelve (12) animals in each: Group 1 served as control, group 2 received glyphosate at a dose of 500 mg/kg b.wt, group 3 received Vitamin C at a dose of 250 mg/kg b.wt and group 4 received glyphosate (500 mg/kg b.wt) and Vitamin C (250 mg/kg b.wt). The treatment regimens were administered by oral gavage once daily for three weeks. The animals were sacrificed on 7th and 21st day post treatment. Results showed a significant increase in the percentage of abnormal sperms, reduction in the levels of testosterone and histopathological changes in the testes of glyphosate treated rats. However, administration of Vitamin C caused a mild to moderate ameliorative effect on the parameters investigated.

Key words: Glyphosate, Testicular Toxicity, Vitamin C, Testosterone and Histopathology






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