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Is there any relationship between glycodelin levels and perinatal outcomes?

Asiye Uzun, Emine Aydin.




Abstract

The aim of this study was to assess the correlation between uterine artery Doppler parameters examined from 20-24 weeks of pregnancy with glycoledin level in maternal blood. The study included 80 patients attending our clinic from September 2019 to June 2020. Participants were divided into two groups according to uterine artery findings. Group 1 included pregnant patients who had abnormal uterine artery Doppler USG at 22–24 weeks of pregnancy, and Group 2 consisted of healthy pregnant patients with uterine artery Doppler USG performed during the same period of pregnancy. Serum glycodelin levels were analyzed at 24 weeks of gestation of two goups and their perinatal outcomes were compared. No significant difference were seen between the groups regarding age, body mass index, blood pressure, gestational age, and blood test sampling time for serum glycodelin analysis. The mean pulsatility index values detected with Doppler ultrasonography were 1.92±0.41 and 0.82±0.25 for Groups 1 and 2, respectively. Comparative analysis revealed that the mean glycodelin level was significantly higher in Group 1 than Group 2 (521.75±21.68 -475.67±41.09; p< 0.001). Glycoledin may assist in predicting negative perinatal outcomes especially preeclampsia. However, many more comperative studies with larger series from multicenter are need to support this conclusion.

Key words: Glycodelin, ultrasonography, doppler ,pregnancy outcome, pre-eclampsia, uterine artery, fetal growth retardation






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