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Experimental substantiation of anti-inflammatory activity of a gel containing Convolvulus arvensis extract in carrageenan-induced aseptic arthritis

Zaynutdinovich Khakimov, Alisher Khudayberdievich Rakhmanov, U B Yakubova, Kodir Shukurlaevich Shukurlaev2.


Abstract

Background: Despite the huge number of drugs used for the treatment of inflammatory diseases, the modern assortment of this group of drugs does not solve the problem of their successful therapy and relapses, the frequency of which after stopping the administration can reach high values.

Aim and Objective: The aim of this work was to study the anti-inflammatory activity of a gel containing Convolvulus arvensis in aseptic arthritis induced by carrageenan.

Materials and Methods: Experimental studies were carried out on sexually mature white males’ rats with an initial weight of 155–180 g. A 5% C. arvensis extract containing gel and 5% ibuprofen gel was applied to the surface of the right hind paw of the animals 1 h before the injection of flogogen and after each measurement of the paw volume. Measurement of the paw volume of animals was carried out using a plethysmometer

Results: A more expressed antiexudative effect was observed when used C. arvensis extract-containing gel. Hence, after 1, 2.3, and 4 h from the beginning of the action of carrageenan, the volume of the rat paws increased compared to the initial by 45.5; 51.9; 59.7; and 51.9%, respectively. An almost twofold inhibition of the development of the exudation process was observed under the influence of C. arvensis extract containing gel in comparison with the control group.

Conclusions: The gel containing the extract of C. arvensis has an expressed antiexudative effect in aseptic arthritis induced by carrageenan. In terms of its antiexudative activity, the preparation containing the extract of C. arvensis is not inferior to ibuprofen when applied locally in the form of a gel.

Key words: Inflammation; Carrageenan; Anti-exudative activity of Convolvulus arvensis extract






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