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J App Pharm Sci. 2023; 13(5): 50-57

Mechanism of action of Indonesian medicinal plants in inhibiting 3T3-L1 adipocyte differentiation: A review

Eko Fuji Ariyanto, Farhan Wirajati, Putri Halleyana Rahman, Afiat Berbudi, Enny Rohmawaty.


Obesity is one of the most serious health problems worldwide, including in Indonesia. One of the strategies to inhibit obesity is modulating adipogenesis, as obesity is associated with the dysregulation of adipogenesis. Adipogenesis is mainly influenced by peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding protein alpha; hence, substances that can inhibit the expression of both transcription factors can be key in obesity management. This review aims to elaborate upon Indonesian medicinal plants that can inhibit adipogenesis in 3T3-L1 adipocytes and their mechanism of action. Original research articles published in 2016–2020 and obtained from PubMed and CINAHL databases were included in this study. From 226 articles, 5 Indonesian medicinal plants (Catharanthus roseus, Chromolaena odorata, Lagerstroemia speciosa, Oroxylum indicum, and Spiranthes sinensis) have been identified to have an inhibitory effect on 3T3-L1 adipogenesis, by suppressing the induction of Pparg, Cebpa, and other adipogenic and lipid metabolism-related genes. Further research is required to identify the responsible chemical compounds that yield this effect and to elaborate on the mechanisms by which these compounds inhibit the induction of adipogenic genes.

Key words: 3T3-L1 cells, Adipogenesis, C/EBPα, Indonesian medicinal plants, PPARγ, Obesity

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