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Original Article

ECB. 2015; 4(9): 410-413


2-MORPHOLINOETHANESULFONIC ACID CATALYZED ONE POT SYNTHESIS OF ISOINDOLO [2,1-a]QUINAZOLINE AT ROOM TEMPERATURE UNDER ULTRASONICATION

D. S. Bhagat, M. V. Katariya, R. D. Ingle, V. M. Joshi, M. R. Bachhav,R. N. Udavant, R. P. Pawar.




Abstract

An efficient and greener one pot method has been developed for the synthesis of isoindolo[2,1-a]quinazolines using 2-morpholinoethane
sulfonic acid as a water soluble green catalyst at ambient temperature and excellent yield of product. The synergetic effect of 2-
morpholineethane sulfonic acid and ultrasound irradiation process has been also discussed.

Key words: 2-morpholinoethanesulfonic acid, ultrasound, multi-component reactions, 2-carboxybenzaldehyde, isatoic anhydride, aromatic amines, benzylamine






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