Parkinsonís disease (PD) is complex disease characterized by the neurodegeneration in mid brain and loss
of activity of dopaminergic neurons. There are several factors responsible for the development of PD. Both the
extrinsic and intrinsic factors potentiate disease progression and neuronal deterioration. Genetic predispositions
along with the environmental cues can exacerbate PD in old age patients. There are number of genes such as the
alpha synuclein (SNCA), leucine-rich repeat kinase 2 gene (LRRK2), PARK2 and DJ-1. Here we aim to describe
the risks, prevalence and genetic factors responsible for PD and also shed light on their role in disease progression.
Parkinson Disease, therapeutics, genetic viability, prevalence
Exploring the Alzheimer's disease neuroepigenome: recent advances and future trends.
Zhang H, Elefant F
Neural regeneration research. 2022; 17(2): 325-327
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44
Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.
Hernandez-Sapiens MA, Reza-Zald√≠var EE, M√°rquez-Aguirre AL, G√≥mez-Pinedo U, Matias-Guiu J, Cevallos RR, Mateos-D√≠az JC, S√°nchez-Gonz√°lez VJ, Canales-Aguirre AA
Neural regeneration research. 2022; 17(1): 31-37
SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology.
Marques RF, Duncan KE
Neural regeneration research. 2022; 17(2): 266-270
Transcranial magnetic stimulation in animal models of neurodegeneration.
Uzair M, Abualait T, Arshad M, Yoo WK, Mir A, Bunyan RF, Bashir S
Neural regeneration research. 2022; 17(2): 251-265