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Research Article

JCR. 2021; 8(2): 42-48


UNDERSTANDING GENETIC BASIS OF PARKINSONíS DISEASE AND ITS PREVALENCE

Hafiza Aqsa Shaukat, BushraGul,Tayyaba Shan,Dr. AsmaNoureen,Dr.KhalidHussain Rind, ShafiUllah, WaseemAkram,Muhammad Tahir,HiraMubeen,SaimaJabeen,ShahidRaza, NajeebUllah,Yasir Arafat.

Abstract
Parkinsonís disease (PD) is complex disease characterized by the neurodegeneration in mid brain and loss
of activity of dopaminergic neurons. There are several factors responsible for the development of PD. Both the
extrinsic and intrinsic factors potentiate disease progression and neuronal deterioration. Genetic predispositions
along with the environmental cues can exacerbate PD in old age patients. There are number of genes such as the
alpha synuclein (SNCA), leucine-rich repeat kinase 2 gene (LRRK2), PARK2 and DJ-1. Here we aim to describe
the risks, prevalence and genetic factors responsible for PD and also shed light on their role in disease progression.

Key words: Parkinson Disease, therapeutics, genetic viability, prevalence



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