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JCDR. 2020; 11(4): 66-70

Preclinical Study of Derivative of 3-Oxypiridone in Experimental Pre-Eclampsia

Alesya V. Yurakova, Sofya Y.Skachilova, Lyudmila M.Danilenko, Indira S. Kochkarova, Natalia V.Ekimova, Anastasia V. Gureeva, Il'ya S. Rozhkov, Adelaida V. Polyanskaya.


Introduction: Currently, preeclampsia remains a serious multisystem complication of pregnancy, leading to disability of children and maternal mortality. One of the leading theories of pathogenesis is the theory of oxidative stress. Accordingly, the search for new drugs with antioxidant and antihypoxic effects is promising for the prevention and treatment of preeclampsia.

Objective. To study the efficiency of using of 3-oxypiridine derivatesat correction of functional violations occurring in preeclampsia in the experiment.

Methods.The experiment was performed on 140 female white rats of Wistar strain weighing 250-300 g. The studied substances were administered within 7 days from 14 to 21 days of pregnancy.On the 21st day of pregnancy, functional tests and laboratory examination were conducted.
Results. Administration of 3-oxypiridine derivates in animals causes the expressed correction of pathological changes in experimental ADMA-like preeclampsia with the highest effect in a higher dose of the test drug. There was a significant rise in systolic and diastolic blood pressure, respectively, the improvement of microcirculation in the placenta.

Conclusion.The results of this study prove the future outlook of the use of 3-oxypiridine derivates for correction of functional changes in preeclampsia and substantiate the reasonability of further research in this direction.

Key words: preeclampsia, 3-oxypiridine, mexidol, endothelial dysfunction, rats, proteinuria, microcirculation

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